Bisphenol A and ovarian steroidogenesis
نویسندگان
چکیده
منابع مشابه
Bisphenol A disrupts steroidogenesis in human H295R cells.
There is increasing concern over the risk of environmentally relevant doses of bisphenol A (BPA) on human endocrine systems. Effects of BPA on steroidogenesis and the related molecular mechanisms were investigated in H295R human adenocarcinoma cells. This immortal cell line is unique in expressing all the enzymes of the steroidogenic pathways. The effects of BPA on steroidogenesis, 17β-estradio...
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Previous investigations in the female blowfly Phormia regina have shown that 3-isobutyl-1-methylxanthine (IBMX), a broad spectrum inhibitor of phosphodiesterases (PDEs), fails to mimic the steroidogenic effects of cAMP on ovaries, although it efficiently increases the concentrations of this second messenger. In this study, experiments carried out to clear up this contradiction demonstrated that...
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Only a minute fraction of ovarian follicles present in a foetal ovary will complete the path to ovulation. The majority of the follicles will instead undergo atresia, a hormonally controlled apoptotic process. Apoptosis occurs throughout follicle development, with an extensive reduction in the number of follicles present at birth. Interestingly, this drastic reduction is not present among preov...
متن کاملBisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) an...
متن کاملAloe Vera Ameliorates Ovarian Toxicity Induced by Bisphenol A in Wistar Rats
Background & Objective: Bisphenol A (BPA) is a hazardous environmental pollutant, which is known to cause ovarian toxicity. The present study aimed to assess the protective effects of Aloe vera herbal extract against ovarian toxicity caused by BPA in Wistar rats. Materials & Methods: The sample population of this experimental study consisted of 40 adult female Wistar rats with a mean weight ...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2016
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2016.08.021